![]() Patients received docetaxel- (82%) or mitoxantrone-based chemotherapy. Multivariate Cox regression analysis was performed to isolate the impact of PSA-DT on OS, controlling for associate prognostic covariates. Survival rates according to PSA-DT were stratified on chemotherapy regimen. The primary endpoint was overall survival (OS). PSA-DT was calculated as ln 2 divided by the slope of the log PSA line, and the difference between two log PSA levels was divided by the time interval. ![]() At least three PSA assays were required within 3 months before chemotherapy. ![]() We evaluated the possible use of prostate-specific antigen doubling time (PSA-DT) before chemotherapy initiation as a surrogate marker of survival in hormone-refractory prostate cancer (HRPC) patients.ĭata from 250 consecutive metastatic HRPC patients treated with chemotherapy between February 2000 and November 2006 were retrospectively analysed.
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